Spinnaker Biosciences is developing porous silicon, porous silicon oxide, and porous silicon/polymer composite materials with uniquely designed optical, chemical, and structural features that make ideal controlled release drug delivery vehicles. Porous silicon has been successfully used in vivo owing to its inherent biocompatibility and biodegradable nature. Additionally, the large porous volume of these particles allows for protected storage and sustained delivery of a therapeutic payload while the versatile surface chemistry enables incorporation of targeting moieties such as peptides, antibodies, or encapsulating biopolymers.  Preclinical animal studies have demonstrated these silicon-based particles to be biocompatible and biodegradable with a dissolution profile that matches the drug release profile.

  • Reproducible manufacturing method
  • Generates porous “nano-sponge” for drugs
  • Accommodates a wide range of drugs and drug delivery rates
  • Manufactured as either microparticles or nanoparticles
  • Biocompatible
  • Injectable
  • Self-indicating residual life
Safe Sustained Drug Delivery using Nanoporous Silicon Particles